2 4-Difluorobenzoic acid (CAS# 1583-58-0)

Aikace-aikace

2, 4-difluorobenzoic acid ne mai mahimmanci magani da magungunan kashe qwari tsaka-tsaki, kamar 2, 4-difluorobenzoic acid da aka yafi amfani da su hada antifungal kwayoyi fluconazole, voriconazole da miyagun ƙwayoyi pesticide matsakaici 4-fluorosalicylic acid, miyagun ƙwayoyi matsakaici 3, 5-difluoroaniline, da dai sauransu 2, 4-difluorobenzoic acid kuma za a iya amfani dashi a cikin ruwa crystal kayan aiki, wanda ke da fa'idodi na babban darajar da kyakkyawan tsammanin kasuwa.

Shiri

Ƙara 2, 4-dinitrotoluene da ruwa zuwa jirgin ruwa, daidaita ƙimar pH zuwa 7, motsawa da zafi zuwa 75 ° C. Potassium permanganate, magnesium sulfate da kuma lokaci canja wurin mai kara kuzari an kara a batches. Bayan ƙarawa, ci gaba da motsawa kuma mayar da martani a yawan zafin jiki na tsawon sa'o'i 3. Tace da zafi sai a wanke tace cake da ruwan zafi. Haɗa tacewa, acidify tare da 35% hydrochloric acid zuwa pH 2-3, akwai adadi mai yawa na farar hazo bayan lu'ulu'u sun cika gaba ɗaya, tacewa, wanke, sake sakewa, da bushe don samun farin lu'ulu'u kamar 2,4-dinitrobenzoic acid. . Matsakaicin 2, 4-dinitrotoluene zuwa potassium permanganate shine 2.4: 1. Yawan samfurin wannan matakin shine 90.7%.

ƙara N, N-dimethylphthalamide a cikin akwati mai amsawa, zafi zuwa 100 ~ 110 ℃, preheat don 0.5 ~ 1h. Add dried anhydrous potassium fluoride a karkashin motsawa kuma kiyaye zafin jiki preheated na 0.5-1h. Bayan haka, an ƙara 2, 4-dinitrobenzoic acid da hexyltrimethylammonium bromide da sauri a cikin jirgin ruwa a lokaci ɗaya, kuma an ci gaba da dumama zuwa 120 ℃, ana kiyaye zafin jiki kuma an ci gaba da motsa jiki. Bayan 7h na reflux dauki, da sauran ƙarfi da aka dawo dasu ta hanyar distillation, sa'an nan kuma dauki ruwa distilled da tururi. Juzu'in da aka tattara shine farin emulsion. Bayan tsayawa na wani lokaci, juzu'in maƙasudin mai mai yana nutsewa zuwa ƙasa, an zubar da farin ruwa mai tsabta a ɓangaren sama, kuma ana sanyaya mai don haɓaka farin lu'ulu'u don samun ɗanyen samfur; da ɗanyen samfurin an sake yin recrystallized, Suction tacewa, wanka, da bushewa don samun farin lu'ulu'u na 2,4-difluorobenzoic acid. Matsakaicin adadin 2, 4-dinitrobenzoic acid zuwa potassium fluoride shine 2.7: 1. Yawan samfurin wannan matakin shine 72.4%.

Gabatarwa
2,4-Difluorobenzoic acid wani fili ne na kwayoyin halitta. Mai zuwa shine gabatarwa ga kaddarorin, amfani, hanyoyin shirye-shirye da bayanan aminci na 2,4-difluorobenzoic acid:

inganci:
- Bayyanar: 2,4-Difluorobenzoic acid wani farin crystalline ne mai ƙarfi.
- Solubility: Yana narkewa a cikin kaushi na gama gari kamar ethanol, methanol da methylene chloride.

Amfani:
- Kayan kayan gani: Hakanan ana iya amfani dashi azaman ɗayan albarkatun ƙasa don shirye-shiryen kayan gani da fina-finai na gani.
- Aikace-aikace na masana'antu: 2,4-difluorobenzoic acid za a iya amfani dashi a cikin masana'antun lantarki, kayan shafa da masana'antun filastik tare da lalata, anti-oxidation da anti-ultraviolet effects.

Hanya:
- 2,4-Difluorobenzoic acid za a iya samu ta hanyar fluorination na hydrofluoric acid tare da p-methylanisole.

Bayanin Tsaro:
- Lokacin aiki, yakamata a guji ƙura don guje wa shaƙar numfashi da kuma haɗa ido. A lokaci guda, ya kamata a kula da yanayin samun iska mai kyau.
- Guji hulɗa tare da magunguna masu ƙarfi ko acid mai ƙarfi don guje wa halayen haɗari