2-Chloro-3-fluoro-6-picoline (CAS# 374633-32-6)

Gabatarwa

Bayyanar: Yawancin lokaci mara launi zuwa ruwan rawaya mai haske, wannan yanayin bayyanar yana nuna cewa yana iya zama mai kula da haske da zafi, kuma wajibi ne a dauki matakan kauce wa haske da zafin jiki yayin ajiya da sufuri, kamar yin amfani da kwalabe na gilashin launin ruwan kasa da adana su. a cikin ɗakin ajiya mai sanyi don hana ƙarin zurfafa launi da lalacewa.

Solubility: Filin yana da kyawawa mai kyau a cikin abubuwan da ake amfani da su na yau da kullum, irin su toluene da dichloromethane, suna bin ka'idar irin wannan solubility, kuma yana da dangantaka da kwayoyin halitta ta hanyar yanayin hydrophobic na kwayoyin halitta; Duk da haka, mai narkewa a cikin ruwa yana da ƙasa, kuma ƙaƙƙarfan haɗin hydrogen tsakanin kwayoyin ruwa yana da wuyar karya yadda ya kamata ta hanyar kwayoyin, yana da wuya a tarwatsa shi.
Ma'anar tafasa da yawa: Bayanan tafasa yana da alaƙa da ƙayyadaddun yanayinsa kuma yana iya samar da mahimman sigogi don ayyuka kamar distillation da tsarkakewa, amma abin takaici takamaiman ƙimar ma'anar tafasa ba a bayyana ko'ina ba. Yawansa ya ɗan fi na ruwa sama, kuma fahimtar yawan ƙima na iya taimakawa wajen ƙididdige alaƙar juzu'in juzu'i a cikin ayyukan gwaji ko hanyoyin masana'antu kamar canja wurin ruwa da ma'auni daidai.
Abubuwan sinadaran
Halin musanya: Atom ɗin chlorine da atom ɗin fluorine a cikin kwayoyin sune wuraren da zasu iya amsawa. A cikin halayen maye gurbin nucleophilic, nucleophiles masu ƙarfi zasu iya kai hari wuraren da chlorine da furotin atom suke, maye gurbin kwayoyin halitta masu kama da juna, kuma su haifar da sababbin abubuwan pyridine. Alal misali, an haɗa shi da wasu nau'o'in nucleophiles masu dauke da nitrogen da sulfur don haɓaka jerin kwayoyin heterocyclic masu dauke da nitrogen tare da tsarin da ya fi dacewa don gano magunguna ko haɗin kayan aiki.
Redox halayen: zoben pyridine da kansa yana da kwanciyar hankali, amma lokacin da aka haɗa da karfi mai karfi, irin su potassium permanganate da hydrogen peroxide tare da yanayin acidic, oxidation na iya faruwa, wanda ya haifar da lalacewa ko gyare-gyaren tsarin zoben pyridine; Sabanin haka, tare da wakili mai dacewa mai ragewa, kamar ƙarfe hydrides, yana yiwuwa a ka'ida yana yiwuwa zuwa hydrogenation na intramolecular unsaturated bonds.
Na hudu, hanyar hadawa
Hanyar haɗakarwa ta gama gari ita ce farawa daga sassauƙan abubuwan pyridine kuma sannu a hankali gina tsarin manufa ta hanyar halogenation da halayen fluorine. Abubuwan da aka fara farawa pyridine mahadi an fara zaɓin methylated kuma an gabatar da ƙungiyoyin methyl a lokaci guda; Sannan yi amfani da reagents na halogenation, irin su chlorine da chlorine ruwa, tare da abubuwan haɓakawa masu dacewa da yanayin amsawa, don cimma shigar da ƙwayoyin chlorine; A ƙarshe, an yi amfani da reagents masu haske, kamar Selectfluor, don daidaita wurin da aka yi niyya daidai don samun 2-chloro-3-fluoro-6-methylpyridine.
Amfani
Magungunan ƙwayoyin cuta suna tsaka-tsaki: tsarinsa na musamman yana ƙaunar masanan magunguna, kuma yana da matsakaicin matsakaici don haɓaka sababbin kwayoyin cutar antibacterial, antiviral, da antitumor. Kayayyakin lantarki da tsarin sararin samaniya na zoben pyridine da masu maye gurbinsu na iya ɗaure musamman ga sunadaran sunadaran a cikin vivo, kuma ana tsammanin za a canza su zuwa kayan aiki masu aiki tare da ingantaccen inganci bayan gyare-gyaren matakai da yawa na gaba.
Kimiyyar Material: A fagen haɗin kayan halitta, ana iya amfani da shi don kera kayan aikin polymer, kayan kyalli, da sauransu, ta hanyar ikonsa na gabatar da daidaitaccen chlorine, atom ɗin fluorine da tsarin pyridine, kayan kyauta tare da lantarki na musamman da na gani. kaddarorin, da kuma inganta haɓakar fasahar fasaha kamar kayan fasaha da kayan nuni.