4-Bromo-3-fluorobenzoic acid (CAS# 153556-42-4)
Bayanan Bayani
| Amfani | 4-bromo-3-fluorobenzoic acid wani muhimmin sinadari ne danyen abu wanda za'a iya amfani dashi don shirya magunguna iri-iri (kamar maganin ciwon daji benzamit). |
| Hanyar hadawa | 4-bromo-3-fluorobenzoic acid za a iya samu ta hanyar hadawan abu da iskar shaka na 4-bromo-3-fluorotoluene ta hanyar potassium permanganate. (1) hadawan abu da iskar shaka: 100kg na kg4-bromo -3-fluorotoluene, 120kg na ruwa da 0.1kg na m barasa polyether sodium sulfate (AES) ana bi da bi zuwa K-400L gilashin-layi dauki kwandon shara (kerarre ta Jiangsu masana'antu rufi sinadaran Equipment Co., Ltd.) sa'an nan 167kg na potassium permanganate an kara a hankali a karkashin yanayin motsawa, a ajiye shi a cikin yanayin tafasa, kuma a mayar da martani na tsawon sa'o'i 9, dakatar da amsa bayan maganin reflux ba shi da beads mai; (2) Tacewa: tace maganin amsawa da aka samu a mataki (1) yayin zafi don samun tacewa wanda ke dauke da samfurin 4-bromo -3-fluorobenzoic acid; (3) Cire potassium permanganate: Domin cire sauran potassium permanganate a cikin tacewa, 0.1kg na sodium sulfite dole ne a ƙara zuwa tacewa da aka samu a mataki (2), ƙarin adadin sodium sulfite ya dogara ne akan ruwa mai tsabta tare da ruwa mai tsabta tare da ruwa mai tsabta tare da ruwa mai tsabta. launin ruwan hoda na maganin. (4) acidification: a cikin yanayin motsawa, sannu a hankali ƙara abu zuwa maganin da aka samu a mataki (3) tare da maida hankali na 12mol / L mai daɗaɗɗen hydrochloric acid. Lokacin da ƙimar pH na maganin shine 2.2, dakatar da ƙara yawan hydrochloric acid kuma ci gaba da amsawa na 30min. (5) crystallization: a cikin yanayin motsawa, maganin da aka samu a mataki (4) an sanyaya shi zuwa 2 ° C, kuma lu'ulu'u da aka yi a cikin maganin sune 4-bromo-3-fluorobenzoic acid. A lokacin aikin, dole ne a ci gaba da motsawa, in ba haka ba 4-bromo-3-fluorobenzoic acid zai haifar da babban ƙarfi, wanda ke da wuya a magance shi a cikin matakai masu zuwa; (6) Tacewa da wankewa: Gaurayen ruwa mai ɗauke da 4-bromo-3-fluorobenzoic acid lu'ulu'u da aka samu a mataki (5) an centrifuged don samun kek ɗin tacewa wanda shine ɗanyen 4-bromo-3-fluorobenzoic acid samfurin, ɗanyen samfurin. ana wanke shi da ruwa mai tsafta kuma an sanya shi a tsakiya (ta yin amfani da centrifuge tare da aikin wankewa) don samun tsaftacewa. 4-bromo-3-fluorobenzoic acid; (7) Drying: 4-bromo-3-fluorobenzoic acid mai ƙarfi wanda aka shirya a mataki (6) an bushe shi a 75 ° C na tsawon sa'o'i 12 don samun 197 kg4-bromo-3-fluorobenzoic acid, abun ciki wanda ya fi 98 %. |
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