5-Fluorocytosine (CAS# 2022-85-7)
Hadari da Tsaro
| Lambobin haɗari | R40 - Shaida mai iyaka na tasirin cutar sankara R36 / 37/38 - Haushi ga idanu, tsarin numfashi da fata. R63 - Haɗarin cutarwa ga ɗan da ba a haifa ba |
| Bayanin Tsaro | S22 - Kada ku shaka kura. S24/25 - Guji hulɗa da fata da idanu. S45 - Idan akwai haɗari ko kuma idan kun ji rashin lafiya, nemi shawarar likita nan da nan (nuna alamar a duk lokacin da zai yiwu.) S36/37 - Sanya tufafin kariya da safar hannu masu dacewa. S36 / 37/39 - Sanya tufafin kariya masu dacewa, safar hannu da kariya / ido / fuska. S27 – Cire duk gurbatattun tufafi nan da nan. S26 - Idan ana hulɗa da idanu, kurkura nan da nan da ruwa mai yawa kuma ku nemi shawarar likita. |
| WGK Jamus | 2 |
| RTECS | HA604000 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29335990 |
| Bayanin Hazard | Mai Guba/Haske Mai Hankali |
| Matsayin Hazard | M, HASKEN SENS |
| Guba | LD50 a cikin mice (mg/kg):>2000 baki da sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS# 2022-85-7) Gabatarwa
inganci
Wannan samfurin fari ne ko fari-farin lu'u-lu'u, mara wari ko ɗan wari. Dan kadan mai narkewa a cikin ruwa, solubility na 1.2% a 20 ° C a cikin ruwa, dan kadan mai narkewa a cikin ethanol; Yana kusan rashin narkewa a cikin chloroform da ether; Mai narkewa a cikin dilute hydrochloric acid ko dilute sodium hydroxide bayani. Yana da tsayayye a cikin zafin jiki, yana zubar da lu'ulu'u lokacin sanyi, kuma an canza ƙaramin sashi zuwa 5-fluorouracil lokacin zafi.
Wannan samfurin maganin rigakafin fungal ne wanda aka haɗa a cikin 1957 kuma ana amfani dashi a cikin aikin asibiti a cikin 1969, tare da tasirin ƙwayar cuta a zahiri akan Candida, cryptococcus, fungi mai canza launin da Aspergillus, kuma babu wani tasiri mai hanawa akan sauran fungi.
Tasirin hanawa akan fungi shine saboda shigarsa cikin sel na fungi masu mahimmanci, inda a ƙarƙashin aikin nucleopyine deaminase, yana cire rukunin amino don samar da antimetabolite-5-fluorouracil. An canza ƙarshen zuwa 5-fluorouracil deoxynucleoside kuma yana hana thymine nucleoside synthetase, yana toshe jujjuyawar uracil deoxynucleoside zuwa thymine nucleoside, kuma yana shafar haɗin DNA.
amfani
Antifungals. An fi amfani dashi don maganin candidiasis na mucocutaneous, candidal endocarditis, candidal arthritis, cryptococcal meningitis da chromomycosis.
Amfani da sashi na baka, 4 ~ 6g a rana, an raba zuwa sau 4.
tsaro
Ya kamata a rika duba adadin jinin a kai a kai yayin gudanar da mulki. Marasa lafiya da ciwon hanta da gazawar koda da cututtukan jini da mata masu juna biyu suyi amfani da hankali; Contraindicated a cikin marasa lafiya tare da rashin ƙarfi na koda.
Shading, ajiyar iska.
