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5-Fluorouracil (CAS# 51-21-8) Hoton da aka Fitar
  • 5-Fluorouracil (CAS# 51-21-8) 1

5-Fluorouracil (CAS# 51-21-8)

Abubuwan Sinadarai:

Tsarin kwayoyin halitta Saukewa: C4H3FN2O2
Molar Mass 130.08
Yawan yawa 1.4593 (ƙididdiga)
Matsayin narkewa 282-286 ° C (dare) (lit.)
Matsayin Boling 190-200°C/0.1mmHg
Ruwan Solubility 12.2 g/L 20ºC
Solubility Dan kadan mai narkewa a cikin ethanol. Yana kusan rashin narkewa a cikin chloroform kuma yana narkar da shi a cikin maganin sodium hydroxide.
Bayyanar Fari ko fari kamar crystalline foda
Launi fari
Merck 14,4181
BRN 127172
pKa pKa 8.0 ± 0.1 (H2O) (Ba a tabbata ba); 3.0 ± 0.1 (H2O) (Rashin tabbas)
PH 4.3-5.3 (10g/l, H2O, 20℃)
Yanayin Ajiya 2-8 ° C
Kwanciyar hankali Barga. Haske mai hankali. Mai ƙonewa. Rashin jituwa tare da ma'aikatan oxidizing masu ƙarfi, tushe mai ƙarfi.
M Hankalin iska
Fihirisar Refractive 1.542
MDL Saukewa: MFCD00006018
Abubuwan Jiki da Sinadarai Matsayin narkewa 282-286°C ( Dec.)(lit.)Yanayin ajiya Ajiye a 0-5
Solubility H2O: 10 mg/ml, bayyananne

siffan foda

farin launi

Solubility na ruwa 12.2g/L 20 oC
Iska mai hankali
14,4181
Farashin 127172
Amfani Don ciwon daji na tsarin narkewa, kansar kai da wuyansa, ciwon gynecological, kansar huhu, ciwon hanta, kansar mafitsara da maganin kansar fata.

Cikakken Bayani

Tags samfurin

Lambobin haɗari R22 - Yana cutarwa idan an haɗiye shi
R20/21/22 - Cutarwa ta hanyar shakarwa, a cikin hulɗa da fata kuma idan an haɗiye shi.
R52 - Yana cutar da halittun ruwa
R25 - Mai guba idan an haɗiye shi
Bayanin Tsaro S36 - Sanya tufafin kariya masu dacewa.
S36/37 - Sanya tufafin kariya da safar hannu masu dacewa.
S36 / 37/39 - Sanya tufafin kariya masu dacewa, safar hannu da kariya / ido / fuska.
S22 - Kada ku shaka kura.
S45 - Idan akwai haɗari ko kuma idan kun ji rashin lafiya, nemi shawarar likita nan da nan (nuna alamar a duk lokacin da zai yiwu.)
S26 - Idan ana hulɗa da idanu, kurkura nan da nan da ruwa mai yawa kuma ku nemi shawarar likita.
ID na UN UN 2811 6.1/PG 3
WGK Jamus 3
RTECS YR035000
FLUKA BRAND F CODES 10-23
Farashin TSCA T
HS Code 29335995
Bayanin Hazard Haushi/Mai Yawan Dafi
Matsayin Hazard 6.1
Rukunin tattarawa III
Guba LD50 baki a cikin zomo: 230 mg/kg

 

Gabatarwa

An fara canza wannan samfurin zuwa 5-fluoro-2-deoxyuracil nucleotides a cikin jiki, wanda ke hana thymine nucleotide synthase kuma yana toshe jujjuyawar deoxyuracil nucleotides zuwa deoxythymine nucleotides, don haka yana hana DNA biosynthesis. Bugu da ƙari, ta hanyar hana shigar da uracil da rotic acid cikin RNA, ana samun tasirin hana haɗin RNA. Wannan samfurin takamaiman magani ne na sake zagayowar tantanin halitta, galibi yana hana ƙwayoyin sel S.

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