Boc-Asp-OtBu (CAS# 34582-32-6)

Gabatarwa

Boc-Asp-OtBu, wanda aka fi sani da Boc-Asp-OtBu, wani abu ne na halitta. Mai zuwa gabatarwa ne ga wasu kaddarorinsa, amfaninsa, tsarawa da bayanan aminci:

Hali:

-Bayyana: crystalline mara launi ko foda.

-Tsarin kwayoyin halitta: C≡H≡NO-7.

-Nauyin kwayoyin halitta: 393.47g/mol.

- Matsakaicin narkewa: kusan 68-70 ° C.

-Solubility: Mai narkewa a cikin wasu kaushi na halitta, irin su dimethylformamide (DMF) da dichloromethane (DCM).

Amfani:

- Boc-Asp-OtBu ƙungiyar kariya ce da aka saba amfani da ita, galibi ana amfani da ita a cikin haɗin peptides da mahadi masu gina jiki. Yana iya kare ƙungiyoyin carboxyl da amino acid na glutamic acid (Asp) da hana halayen haɗari da lalacewa.

- Boc-Asp-OtBu kuma za'a iya amfani dashi azaman matsakaiciyar amsawa a cikin haɗaɗɗun kwayoyin halitta, kamar a cikin kirar peptide da haɗin magunguna.

Hanyar Shiri:

-Yawanci, Boc-Asp-OtBu ana shirya shi ta hanyar amsa daidai amino acid (L-glutamic acid) tare da ƙungiyar kariyar tert-butyl (Boc) da ƙungiyar kariyar tert-butoxycarbonyl (OtBu). Ana aiwatar da aikin a ƙarƙashin yanayin da ya dace, misali ta hanyar ƙari na mai kunnawa kamar 1- (trimethylsilyl) -1H-pyrazol-3-one (TBTU) ko N, N'-diisopropylmethylamide (DIPCDI) a cikin ƙwayar ƙwayar cuta.

Bayanin Tsaro:

- Boc-Asp-OtBu tare da ƙarancin guba.

-Saboda sinadarin halitta ne, a guji shakar kura ko haduwa da fata da idanu.

-Lokacin da ake aiki, kuna buƙatar bin matakan tsaro na dakin gwaje-gwaje masu dacewa, kamar sanya safar hannu na kariya da kariya ta ido.

-Lokacin da ake adanawa, sai a ajiye shi a wuri mai sanyi, busasshiyar, kuma daga wuta da abubuwan da ke haifar da iskar oxygen.

Abubuwan da ke sama don tunani ne kawai, da fatan za a bi daidaitattun ƙayyadaddun aikin gwajin sinadarai lokacin amfani da sarrafa Boc-Asp-OtBu.