BOC-GLY-GLY-GLY-OH (CAS# 28320-73-2)

Gabatarwa

Tert-Butoxycarbonylglycyl glycylglycine (Boc-Gly-Gly-Gly-OH) wani fili ne na kwayoyin halitta tare da kaddarorin masu zuwa:

Hali:

-Bayyana: yawanci fari crystal ko crystalline foda

-Tsarin kwayoyin halitta: C17H30N4O7

-Nauyin kwayoyin halitta: 402.44g/mol

-Mai narkewa: game da 130-132 ° C

-Solubility: Soluble a cikin kwayoyin kaushi irin su dimethylformamide (DMF), dichloromethane, chloroform, da dai sauransu, wanda ba a iya narkewa cikin ruwa.

Amfani:

Boc-Gly-Gly-Gly-OH ana amfani da su sosai a cikin haɗin gwiwar kwayoyin halitta, galibi azaman ƙungiyoyi ko ƙungiyoyi masu kariya. Ana iya amfani da shi azaman ƙungiyar kariya ta amino acid don hana halayen da ba na musamman ba, kuma ana amfani da shi sosai a cikin ƙayyadaddun lokaci mai ƙarfi, kira na peptide da haɗin magunguna.

Hanya:

Hanyar gama gari don shirya Boc-Gly-Gly-Gly-OH ita ce gabatar da ƙungiyar kariyar tert-butoxycarbonyl akan ƙungiyar carboxyl na glycine. Takamaiman matakai sun haɗa da:

1. Glycine yana amsawa tare da cakuda sodium nitrite da sulfuric acid don samun tert-butoxycarbonyl glycinate.

2. An cire ƙungiyar kare Ester ta hanyar maganin hydrolysis don samun Boc-glycine.

3. Maimaita matakan da ke sama sau biyu don gabatar da ƙungiyar carboxyl na glycine zuwa ƙungiyoyin kariyar tert-butoxycarbonyl biyu bi da bi don samun Boc-Gly-Gly-Gly-OH.

Bayanin Tsaro:

Yin amfani da Boc-Gly-Gly-Gly-OH ya kamata ya kula da waɗannan batutuwan aminci:

-A guji cudanya da fata da idanu, domin yana iya harzuka fata da idanu.

-A sa safofin hannu masu kariya, tabarau da tufafin kariya yayin aiki.

-Ayi aiki a wuri mai kyau don gujewa shakar kura ko tururinsa.

-ya kamata a adana shi daga wuta, zafi da oxidant, ajiye akwati a rufe, adana shi a wuri mai sanyi, bushe.