BOC-L-Phenylglycine (CAS# 2900-27-8)

Gabatarwa

N-Boc-L-Phenylglycine wani fili ne na kwayoyin halitta wanda aka kafa ta hanyar samuwar haɗin sinadarai tsakanin rukunin amino (NH2) na glycine da ƙungiyar carboxyl (COOH) na benzoic acid. Tsarinsa yana ƙunshe da ƙungiyar kariya (Ƙungiyar Boc), wacce ita ce ƙungiyar tert-butoxycarbonyl, wacce ake amfani da ita don kare sake kunnawar rukunin amino.

N-Boc-L-phenylglycine yana da kaddarorin masu zuwa:

- Bayyanar: Farar crystalline m

- Solubility: Mai narkewa a cikin wasu kaushi na halitta, kamar dimethylformamide (DMF), dichloromethane, da sauransu.

N-Boc-L-phenylglycine yawanci ana amfani dashi a cikin halayen matakai masu yawa a cikin haɓakar ƙwayoyin cuta, musamman don haɓakar mahaɗan peptide. Ƙungiyar kare Boc na iya zama ta hanyar yanayin acidic, ta yadda ƙungiyar amino zata iya yin aiki sannan kuma ta aiwatar da halayen da suka biyo baya. Hakanan za'a iya amfani da N-Boc-L-phenylglycine azaman abin haɓaka don gina cibiyoyin chiral a cikin haɗin peptide.

Shirye-shiryen N-Boc-L-phenylglycine galibi ana aiwatar da su ta hanyoyi masu zuwa:

Glycine yana esterified tare da benzoic acid don samun benzoic acid-glycinate ester.

Yin amfani da maganin lithium borotrimethyl ether (LiTMP), an samar da benzoic acid-glycinate ester kuma an amsa tare da Boc-Cl (tert-butoxycarbonyl chloride) don samun N-Boc-L-phenylglycine.

- N-Boc-L-phenylglycine na iya zama mai ban haushi ga idanu, fata, da fili na numfashi kuma ya kamata a kauce masa yayin amfani.

- Ya kamata a sa kayan kariya na sirri kamar safofin hannu na dakin gwaje-gwaje, gilashin aminci, da sauransu yayin aiki.

- Ya kamata a yi shi a cikin yanayin dakin gwaje-gwaje mai isasshen iska.

- Ka guji haɗuwa da oxidants da acid mai ƙarfi lokacin adanawa.

- Idan an haɗiye ko an shaka, a nemi kulawar likita nan da nan, kawo kwantena na fili, sannan a ba wa likita bayanan lafiya da suka dace.