Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8)

Gabatarwa

Z-Glu-OBzl (Z-Glu-OBzl) wani fili ne na halitta wanda aka saba amfani dashi azaman rukunin kariya don amino acid. Mai zuwa shine bayanin kaddarorin, amfani, shiri da bayanan aminci na fili:

Hali:

-Tsarin kwayoyin halitta: C17H17NO4

-Nauyin kwayoyin halitta: 303.32g/mol

-Bayyana: Farin lu'ulu'u foda

-Mai narkewa: 84-85°C

-Solubility: Soluble a cikin kwayoyin kaushi irin su dimethyl sulfoxide da dimethylformamide

- Ƙungiyar kare Cbz za a iya cire ta ta palladium hydride catalyst a ƙarƙashin yanayin acidic

Amfani:

- Z-Glu-OBzl rukuni ne mai kariya na glutamic acid (Glu), wanda za'a iya amfani dashi a cikin haɗin amino acid, polypeptides da sunadarai.

-A matsayin ƙungiyar kariya ga amino acid a cikin mahaɗan kwayoyin halitta, yana iya kare ƙungiyar aminin glutamic acid, hana shi daga tasirin abubuwan da ba na musamman ba, da sauƙaƙe cirewa lokacin da ake buƙata.

Hanyar Shiri:

-Shirye-shiryen Z-Glu-OBzl yawanci ya haɗa da matakai masu yawa kuma ya ƙunshi jerin halayen sinadaran. Ɗaya daga cikin hanyoyin gama gari shine fara kare ƙungiyar carboxyl na glutamic acid a matsayin t-butoxycarbonyl ester (Boc) sannan a kare rukunin amino kamar Cbz. A ƙarshe, samfurin da ake so Z-Glu-OBzl yana samuwa ta hanyar amsawa tare da benzyl chloroformate.

Bayanin Tsaro:

- Z-Glu-OBzl ya kamata a kula da shi azaman mahadi masu ban haushi kuma a guji haɗuwa da fata da idanu kai tsaye.

-Lokacin da aka yi amfani da shi a dakin gwaje-gwaje, dole ne a bi ingantattun hanyoyin aminci, gami da sanya gilashin kariya, safar hannu da riguna na dakin gwaje-gwaje.

-A nisanci shaka ko sha a wurin sannan a dauki matakan kariya daga wuta da fashewa yayin ajiya.

-Ya kamata a sanya wurin a cikin yanayi mai kyau yayin sarrafawa, kuma a zubar da sharar da kyau daidai da dokokin gida.