dabigatran etexilate (CAS# 211915-06-9)

Abubuwan Sinadarai:

Tsarin kwayoyin halitta	Saukewa: C34H41N7O5
Molar Mass	627.73
Yawan yawa	1.24± 0.1 g/cm3 (An annabta)
Matsayin narkewa	128-129 °
Matsayin Boling	827.9°C a 760 mmHg
Wurin Flash	454.5°C
Solubility	DMSO (Dan kadan), methanol (dan kadan)
Tashin Turi	1.49E-27mmHg a 25°C
Bayyanar	M
Launi	Fari zuwa Kodadden Rawaya
pKa	9.88± 0.46 (An annabta)
Yanayin Ajiya	An rufe shi a bushe, adana a cikin injin daskarewa, ƙasa da -20 ° C
Kwanciyar hankali	Hygroscopic
Fihirisar Refractive	1.614
Nazarin in vitro	Dabigatran zaɓaɓɓe kuma a sake juyewa yana hana thrombin ɗan adam (Ki: 4.5 nM) da thrombin-induced platelet aggregation (IC50: 10 nM) kuma ba shi da wani tasiri mai hanawa akan sauran abubuwan da ke motsa platelet. Dabigatran yana hana haɓakar thrombin (PPP) a cikin plasma na raguwar platelet tare da IC50 na 0.56 μm kamar yadda aka auna ta hanyar Indexin thrombin Index (ETP). A cikin gwaje-gwajen in vitro, Dabigatran yana da tasirin maganin jijiyoyi masu dogaro da hankali akan nau'ikan nau'ikan daban-daban. A cikin PPP na ɗan adam, lokacin thromboplastin da aka kunna (aPTT), lokacin prothrombin (PT) an ninka sau biyu a adadin 0.23,0.83 da 0.18 μm, bi da bi. Kuma Ecarin clotting lokaci (ECT).
A cikin nazarin vivo	Adadin Dabigatran wanda ya dogara da tsawaita aPPT bayan gudanarwar jijiya a cikin berayen (0.3,1 da 3 mg/kg) da birai rhesus (0.15,0.3 da 0.6 mg/kg). Dabigatran etexilate (20 mg / kg, PO) ya haifar da ƙarancin tsawaita ƙimar k da ƙarancin haɓakar matsakaicin haɓakar aladu fiye da enoxaparin. Dabigatran (0.01-0.1 mg / kg) kashi-dogara rage thrombosis, tare da ED50 (50% tasiri kashi) kasancewa 0.033 mg / kg da cikakken hanawa a 0.1 mg / kg. Dabigatran etexilate (5-30 mg / kg) ya hana thrombus samuwar thrombus a cikin kashi-da kuma dogara da lokaci, tare da mafi girman hanawa da ke faruwa bayan 30 min na pretreatment, yana nuna sakamako mai sauri.

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Gabatarwa

Dibutyl phthalate wani fili ne na kwayoyin halitta. Ruwa ne mara launi zuwa haske rawaya mai kamshi na musamman.

Dabigatran etexilate ana amfani da shi ne azaman filastik. Yana iya haɓaka laushi da ductility na robobi, don haka ana amfani dashi sosai wajen kera samfuran filastik, kamar fina-finai na filastik, bututun filastik, shimfidar filastik da takalma na filastik. Hakanan za'a iya amfani dashi azaman ƙari ga kaushi, mai mai da kamshi.

Dabigatran etexilate yawanci ana shirya shi ta hanyar esterification na phthalic anhydride tare da n-butanol ko isobutanol. Yawancin lokaci ana aiwatar da halayen a gaban mai haɓaka acid a yanayin da ya dace da matsa lamba.

Yana iya zama mai haushi ga fata da idanu kuma ya kamata a wanke shi da ruwa mai yawa nan da nan bayan haɗuwa. Guji amsawa tare da oxidants, guje wa tushen kunnawa da nesa daga yanayin zafi da buɗe wuta yayin aiki da ajiya. Ya kamata a sami iska sosai yayin amfani don guje wa tara tururi.

Na baya: 2-(4-BROMOPHENYL)PROPAN-2-OL (CAS# 2077-19-2)

Na gaba: 4-Methyl hydrogen L-aspartate (CAS # 2177-62-0)

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