Dodec-11-yn-1-ol (CAS# 18202-10-3)
Dodec-11-yn-1-ol (CAS# 18202-10-3) Bayani
| shiri | NaH (7.5g, 60% watsawar mai, 326mmol) an ƙara batch ta tsari zuwa dodecyl -3-alkyne -1-giya (10.0g,54.95mmol; GF Smith) a cikin 0 ℃ bayani na ethylenediamine (40mL). Bayan awa 1, an ɗaga zafin jiki zuwa 70 ℃. Bayan wani 8h, kwantar da cakuda dauki zuwa 0 ° C, a hankali ƙare tare da ruwan sanyi (100mL), kuma cire tare da ether (3 × 60mL). An wanke kayan haɗin ether da ruwa (100ml). An sake fitar da ruwan wanka tare da ether (3 × 60mL). An tattara abubuwan da aka haɗe da ƙwayoyin halitta a ƙarƙashin vacuum, kuma ragowar sun kasance ƙarƙashin chromatography na shafi ta amfani da 10% EtOAc / hexane don samun 11-dodecyne -1-alcohol (7.4g,74%) gurbata tare da 3-5% na sauran isomers na yanki. regioisomer). TLC: 30% EtOAc/hexane, Rf ≈ 0.4; 1H NMR(300MHz,CDCl3)δ3.66(t,2H,J = 7.3Hz), 2.14-2.21(m,2H),1.93(t,J = 1.9Hz ,1H),1.20-1.63(m,16H). |
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