L-Pyroglutamic acid CAS 98-79-3
Hadari da Tsaro
| Alamomin haɗari | Xi - Haushi |
| Lambobin haɗari | 36/37/38 - Hannun idanu, tsarin numfashi da fata. |
| Bayanin Tsaro | S26 - Idan ana hulɗa da idanu, kurkura nan da nan da ruwa mai yawa kuma ku nemi shawarar likita. S36 - Sanya tufafin kariya masu dacewa. S37/39 - Sanya safofin hannu masu dacewa da kariya / ido |
| WGK Jamus | 3 |
| RTECS | Saukewa: TW3710000 |
| FLUKA BRAND F CODES | 21 |
| Farashin TSCA | Ee |
| HS Code | 29337900 |
| Gabatarwa | pyroglutamic acid shine 5-oxyproline. An kafa shi ta hanyar bushewa tsakanin ƙungiyar α-NH2 da ƙungiyar γ-hydroxyl na glutamic acid don samar da haɗin lactam na kwayoyin halitta; Hakanan ana iya kafa ta ta hanyar rasa ƙungiyar Amido a cikin kwayar glutamine. Idan rashi na glutathione synthetase, na iya haifar da pyroglutamemia, jerin alamun asibiti. Pyroglutamemia cuta ce ta ƙwayoyin acid metabolism da ke haifar da ƙarancin glutathione synthetase. Bayyanar cututtuka na haihuwa 12 ~ 24 hours na farawa, ci gaba hemolysis, jaundice, na kullum Metabolic Acidosis, shafi tunanin mutum cuta, da dai sauransu.; Fitsari ya ƙunshi pyroglutamic acid, lactic acid, Alpha deoxy4 glycoloacetic acid lipid. Jiyya, alamar cututtuka, kula da daidaita abincin bayan shekaru. |
| kaddarorin | L-pyroglutamic acid, kuma aka sani da L-pyroglutamic acid, L-pyroglutamic acid. Daga ethanol da cakuda ether na man fetur a cikin hazo na mazugi mara launi na orthorhombic biyu Crystal, ma'anar narkewa na 162 ~ 163 ℃. Mai narkewa a cikin ruwa, barasa, acetone da acetic acid, ethyl acetate-mai narkewa, mai narkewa a cikin ether. Takamaiman jujjuyawar gani -11.9 °(c = 2,H2O). |
| Features da amfani | a cikin fatar jikin mutum yana ƙunshe da aikin ɗanɗano na abubuwa masu narkewa na ruwa - abubuwan da ke da ɗanɗano na halitta, abun da ke ciki shine kusan amino acid (wanda ya ƙunshi 40%), pyroglutamic acid (mai ɗauke da 12%), salts inorganic (Na, K, Ca, Mg, da sauransu). dauke da 18.5%), da sauran kwayoyin halitta (dauke da 29.5%). Saboda haka, pyroglutamic acid yana daya daga cikin manyan abubuwan da ke cikin fata na yanayi mai laushi na halitta, kuma karfinsa na danshi ya wuce na glycerol da propylene glycol. Kuma ba mai guba ba, babu kuzari, kulawar fata ne na zamani, kayan gyaran gashi na kayan kwalliyar kayan masarufi masu kyau. Pyroglutamic acid kuma yana da tasirin hanawa akan ayyukan tyrosine oxidase, don haka yana hana shigar da abubuwan "melanoid" a cikin fata, wanda ke da tasirin fata akan fata. Yana da tasiri mai laushi akan fata, ana iya amfani dashi don kayan shafawa na ƙusa. Baya ga aikace-aikace a cikin kayan shafawa, L-pyroglutamic acid kuma na iya samar da abubuwan da aka samo asali tare da sauran mahadi na halitta, waɗanda ke da tasiri na musamman akan aikin farfajiya, m da sakamako mai haske, da dai sauransu Hakanan ana iya amfani dashi azaman surfactant don wanka; Chemical reagents don ƙuduri na tseren amines; Matsakaicin kwayoyin halitta. |
| hanyar shiri | L-pyroglutamic acid an kafa shi ta hanyar cire minti daya na ruwa daga kwayoyin L-glutamic acid, kuma tsarin shirye-shiryensa yana da sauƙi, mahimman matakai shine kula da zafin jiki da lokacin bushewa. (1) 500g na L-glutamic acid aka zuba a cikin 100 ml beaker, da kuma beaker da aka mai tsanani da wani mai wanka wanka, da kuma zafin jiki ya tashi zuwa 145 zuwa 150 ° C., da kuma zafin jiki da aka kiyaye na 45 minutes don bushewa. dauki. Maganin rashin ruwa shine Tan. (2) bayan kammala maganin rashin ruwa, an zuba maganin a cikin ruwan zãfi tare da ƙarar kimanin 350, kuma an narkar da maganin gaba daya a cikin ruwa. Bayan sanyaya zuwa 40 zuwa 50 ° C., an ƙara adadin adadin carbon da aka kunna don canza launi (maimaita sau biyu). An sami bayani mai haske mara launi. (3) Lokacin da bayani mara launi mara launi wanda aka shirya a mataki (2) yana mai zafi kai tsaye kuma an kwashe shi don rage ƙarar zuwa kusan rabin, juya zuwa wanka na ruwa kuma ci gaba da maida hankali zuwa ƙarar kimanin 1/3, za ku iya dakatar da dumama, kuma a cikin ruwan zafi mai wanka don jinkirin crystallization, 10 zuwa 20 hours bayan shirye-shiryen lu'ulu'u na prismatic mara launi. Adadin L-pyroglutamic acid a cikin kayan shafawa ya dogara da tsari. Hakanan za'a iya amfani da wannan samfurin akan kayan shafawa a cikin hanyar 50% mai da hankali bayani. |
| glutamic acid | glutamic acid amino acid ne wanda ya ƙunshi furotin, yana da sarkar gefen acidic ionized, kuma yana nuna hydrotropism. Glutamic acid yana da saukin kamuwa zuwa cyclization cikin pyrrolidone carboxylic acid, I.e., pyroglutamic acid. glutamic acid yana da girma musamman a cikin duk sunadaran hatsi, yana samar da alpha-ketoglutarate ta hanyar zagayowar tricarboxylic acid. Alpha ketoglutaric acid za a iya hada kai tsaye daga ammonia a karkashin catalysis na glutamate dehydrogenase da NADPH (coenzyme II), kuma za a iya catalyzed ta aspartate aminotransferase ko alanine aminotransferase, glutamic acid aka samar ta hanyar transamination na aspartic acid ko alanine; Bugu da ƙari, glutamic acid za a iya jujjuya shi tare da proline da ornithine (daga arginine), bi da bi. Glutamate don haka amino acid ne maras amfani da sinadirai. Lokacin da aka lalata glutamic acid a ƙarƙashin catalysis na glutamate dehydrogenase da NAD (coenzyme I) ko kuma an canza shi daga rukunin amino ƙarƙashin catalysis na aminotransferase aspartate ko alanine aminotransferase don samar da alpha ketoglutarate, yana shiga cikin zagayowar tricarboxylic acid kuma yana haifar da sukari ta hanyar Hanyar gluconeogenic, don haka glutamic acid shine muhimmin amino acid glycogenic. glutamic acid a cikin kyallen takarda daban-daban (kamar tsoka, hanta, kwakwalwa, da sauransu) na iya haɗa glutamine tare da NH3 ta hanyar catalysis na glutamine synthetase, shine samfurin detoxification na ammonia, musamman a cikin nama na kwakwalwa, da kuma nau'in ajiya da amfani da su. ammonia a cikin jiki (duba "glutamine da metabolism"). An haɗa glutamic acid tare da acetyl-CoA a matsayin mai haɗin gwiwar mitochondrial carbamoyl phosphate synthase (wanda ke cikin haɗin urea) ta hanyar catalysis na acetyl-glutamate synthase. γ-aminobutyric acid (GABA) samfur ne na decarboxylation na glutamic acid, musamman a cikin babban taro a cikin nama na kwakwalwa, kuma yana bayyana a cikin jini, ana ɗaukarsa aikin physiological a matsayin inhibitory neurotransmitter, da antispasmodic da hypnotic effects. Ana iya samun jiko na asibiti na echinocandin ta hanyar GABA. Catabolism na GABA yana shiga cikin zagayowar tricarboxylic acid ta hanyar canza GABA transaminase da aldehyde dehydrogenase zuwa succinic acid don samar da GABA shunt. |
| Amfani | ana amfani da shi azaman tsaka-tsaki a cikin haɗaɗɗun kwayoyin halitta, abubuwan ƙari na abinci, da sauransu. ana amfani da su a abinci, magunguna, kayan kwalliya da sauran masana'antu |
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