Methoxymethyl triphenylphosphonium chloride (CAS# 4009-98-7)

Amfani

(Methoxymethyl) triphenylphosphorus chloride ana amfani dashi don haɗa cefaltacin, wanda shine maganin rigakafi da ƙwayar cuta. Hakanan ana amfani dashi don haɗa guntun paclitaxel.

Shiri

Hanyar hadawa (methoxymethyl) triphenylphosphorus chloride, wanda ya ƙunshi matakai masu zuwa: ƙarƙashin kariyar nitrogen, ƙara 50mL na acetone anhydrous a cikin reactor, sa'an nan kuma ƙara 32g na triphenylphosphine, motsawa da haɓaka yanayin zafi zuwa 37 ° C, kula da yawan zafin jiki. , ƙara 20g na methyl chloromethyl ether zuwa reactor, sa'an nan kuma mayar da martani a 37 ° C don 3h, sannu a hankali yana haɓaka yawan zafin jiki zuwa 47 ° C a cikin adadin 1 ° C / min, an ci gaba da amsawa don 3h, an dakatar da amsawa, kuma an samu 37.0g (methoxymethyl) triphenylphosphorus chloride ta hanyar tacewa, anhydric. ether wankewa da bushewa tare da yawan amfanin ƙasa na 88.5%.