Methyl 2-cyanoisonicotinate (CAS# 94413-64-6)
Hadari da Tsaro
| Matsayin Hazard | 6.1 |
Hanyar samarwa
An shirya fili da aka yi niyya ta hanyar iskar oxygen, amidation da dehydration tare da methyl 2-methyl 4-pyridinecarboxylate (2) a matsayin kayan farawa. An tabbatar da tsarin sa ta 1H NMR da MS, kuma yawan amfanin ƙasa ya kasance 53.0%. An yi nazarin tasirin rabon ciyarwa, zafin jiki na crystallization, lokacin amsawa da sauran dalilai akan samfurin ta hanyar gwaje-gwaje guda ɗaya, kuma an inganta yanayin tsari: n (2): n (potassium permanganate) = 1.0: 2.5, zafin jiki na crystallization 0 ~ 5 ℃; n (methyl 2-carboxyl -4-pyridinecarboxylate): n (sulfoxide) = 1.0: 1.4, dauki; da rashin ruwa dauki zabi da trifluoroacetic anhydride-trietylamine tsarin a matsayin dehydrating wakili. Tsarin yana da sauƙi don aiki, yanayin amsawa yana da sauƙi, sauƙi don haɓaka samarwa, kuma yana da ƙimar aikace-aikacen aiki mai kyau.
Amfani
Ana amfani da Tobisostat don magance hyperuricemia na kullum na gout. Idan aka kwatanta da maganin gargajiya na allopurinol (analofin purine), ba zai shafi purine da pyridine metabolism da aikin enzyme ba, kuma yana rage uric acid Sakamakon ya fi karfi, ba a buƙatar babban adadin maimaita gudanarwa, kuma aminci ya fi kyau. Methyl 2-cyano-4-pyridine carboxylate wani muhimmin albarkatun kasa ne don haɗakar da Tobiso.
