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Mitotan (CAS# 53-19-0)

Abubuwan Sinadarai:

Tsarin kwayoyin halitta Saukewa: C14H10Cl4
Molar Mass 320.04
Yawan yawa 1.3118 (ƙananan ƙididdiga)
Matsayin narkewa 77-78°C (lit.)
Matsayin Boling 405.59°C
Ruwan Solubility <0.1 g/100 ml a 24ºC
Solubility DMSO: mai narkewa20mg/ml, bayyananne
Bayyanar foda
Launi fari zuwa m
Merck 13,6237 / 13,6237
BRN 2056007
Yanayin Ajiya Yanayin rashin aiki, Zazzabin ɗaki
Fihirisar Refractive 1.6000 (kimanta)
Abubuwan Jiki da Sinadarai Matsayin narkewa 76-78 ° C
ruwa mai narkewa <0.1g/100 ml a 24°C
Amfani Wannan samfurin don binciken kimiyya ne kawai kuma ba za a yi amfani da shi don wasu dalilai ba.
Nazarin in vitro A cikin layin TalphaT1 na linzamin kwamfuta, Mitotane yana hana magana da ɓoyewar TSH, yana toshe amsawar TSH zuwa TRH, kuma yana rage yiwuwar ƙwayoyin sel, kuma yana haifar da apoptosis. A cikin ƙwayoyin linzamin kwamfuta na TSH na pituitary, Mitotane baya tsoma baki tare da hormone thyroid, amma kai tsaye yana rage ayyukan sirri da kuma iyawar salula. Mitotane yana haifar da necrosis na cortical adrenal, lalacewar mitochondrial membrane, da kuma ɗaurin da ba za a iya jurewa ba ga furotin CYP. Mitotane (10-40 μm) ya hana basal da ƙwayar cortisol na caMP amma bai haifar da mutuwar kwayar halitta ba. Mitotane ya nuna tasirin hanawa akan basal STA da sunadaran P450scc. Mitotane (40 μm) ya rage mahimmancin matakan mRNA na STAR, CYP11A1 da cyp21. Mitotane (40 μm) kusan gaba ɗaya ya kawar da shigar da STAR, CYP11A1, CYP17, da CYP21 mRNA ta adenosine 8-bromo-cyclic phosphate. A cikin tsarin S na sel H295R, haɗuwa da Mitotane da gemcitabine sun nuna rashin amincewa kuma sun tsoma baki tare da hanawar gemcitabine a cikin tsarin tantanin halitta.
A cikin nazarin vivo A cikin berayen, Mitotane (60 mg/kg) ya rage girman adrenal mitochondrial da microsomal “P-450” da microsomal sunadaran da 34%,55% da 35%.

Cikakken Bayani

Tags samfurin

Alamomin haɗari Xn - cutarwa
Lambobin haɗari 40 - Ƙayyadadden shaida na tasiri na carcinogenic
Bayanin Tsaro 36/37 - Sanya tufafin kariya da safar hannu masu dacewa.
ID na UN 3249
WGK Jamus 3
RTECS KH788000
HS Code Farashin 290390002
Matsayin Hazard 6.1 (b)
Rukunin tattarawa III

 

Gabatarwa

Mitotane wani fili ne na kwayoyin halitta mai suna N, N'-methylene diphenylamine. Mai zuwa shine gabatarwa ga kaddarorin, amfani, hanyoyin shirye-shirye da bayanan aminci na mitotane:

 

inganci:

- Mitotane wani abu ne mai ƙarfi mara launi wanda ke narkewa a cikin kaushi na halitta kamar ethanol, ether, da chloroform.

- Mitotane yana da wari mai ƙarfi.

 

Amfani:

- Mitotane galibi ana amfani dashi don haɗa halayen haɗin gwiwa a cikin ƙwayoyin halitta kuma galibi ana amfani dashi azaman reagent da mai kara kuzari.

- Yana iya shiga cikin halayen sinadarai iri-iri, kamar haɗakar alkynes, alkylation na mahadi masu kamshi, da sauransu.

 

Hanya:

- Mitotane na iya haɗawa ta hanyar amsawa ta mataki biyu. Formaldehyde yana amsawa tare da diphenylamine a ƙarƙashin yanayin alkaline don samar da N-formaldehyde diphenylamine. Sa'an nan, ta hanyar pyrolysis ko sarrafa iskar oxygen dauki, an canza shi zuwa mitotane.

 

Bayanin Tsaro:

- Mitotane abu ne mai ban haushi kuma bai kamata ya shiga cikin fata da idanu kai tsaye ba. Ya kamata a sanya kayan kariya da suka dace kamar safar hannu, tabarau, da tufafin kariya lokacin aiki.

- Lokacin adanawa da sarrafawa, kula da rufewa da kariya daga haske don guje wa haɗuwa da iska da danshi.

- Mitotane yana raguwa a yanayin zafi mai zafi don samar da iskar gas mai guba, guje wa dumama ko haɗuwa da wasu abubuwa masu ƙonewa.

- Koma zuwa ƙa'idodin gida kuma bi matakan tsaro masu dacewa lokacin zubar da su.


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