N-Boc-N'-tosyl-D-histidine (CAS# 69541-68-0)
Gabatarwa
Boc-D-His (Tos) -OH (Boc-D-His (Tos) -OH) wani sinadari ne wanda ke da abubuwa masu zuwa:
Hali:
1. Bayyanar: farin m
2. dabarar kwayoyin: C21H25N3O6S
3. Nauyin kwayoyin: 443.51
4. Matsayin narkewa: kimanin 110-115 ° C
Amfani:
Boc-D-His (Tos) -OH ana amfani dashi da yawa a cikin ƙwayoyin halitta azaman ƙungiyar karewa don D-histidine (D-His). Babban amfaninsa sun haɗa da:
1. A cikin kira na polypeptide, ana amfani dashi don haɗa nau'in polypeptide wanda ke dauke da ƙungiyar kare D-histidine.
2. An yi amfani da shi azaman tsaka-tsaki a fagen ilmin sinadarai na magani don haɗar mahaɗan abubuwan da ke aiki da ilimin halitta.
3. Zane da kuma kira na mahaɗan ɗan takarar miyagun ƙwayoyi a cikin bincike.
Hanyar Shiri:
Shirye-shiryen Boc-D-His (Tos) -OH yawanci ana aiwatar da su ta matakai masu zuwa:
1. D-histidine (D-His) an amsa tare da p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) don ba da D-histidine p-toluenesulfonyl (D-His-Tos).
2. A karkashin yanayin alkaline, D-His-Tos yana amsawa tare da n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) don samar da Boc-D-His (Tos) -OH.
Bayanin Tsaro:
Ƙididdiga na aminci na Boc-D-His (Tos) -OH yana iyakance, amma a matsayin sinadari, ya kamata a lura da waɗannan la'akarin aminci:
1. A guji shakar numfashi, saduwa da fata da idanu. Saka kayan kariya masu dacewa, kamar safar hannu da tabarau.
2. Ya kamata a bi kyawawan ayyuka na dakin gwaje-gwaje yayin amfani da kuma tabbatar da yanayin samun iska mai kyau.
3. Ajiye a cikin akwati da aka rufe, nesa da wuta da oxidant.
4. Bi ƙa'idodi da jagororin da suka dace yayin aiki.
Lokacin amfani da Boc-D-His(Tos) -OH, da fatan za a tabbatar da bin ƙa'idodin aminci na dakin gwaje-gwaje da umarnin aiki, da adanawa da sarrafa sinadarai yadda ya kamata. Idan ya cancanta, ana ba da shawarar yin aiki a ƙarƙashin jagorancin ƙwararru.
