N-Boc-N'-xanthyl-L-asparagine (CAS# 65420-40-8)

Gabatarwa

N (alpha) -boc-N (gamma)-(9-xanthenyl) -L-asparagine wani fili ne na kwayoyin halitta wanda aka yi amfani da shi sosai a fagen nazarin halittu da kuma magunguna. Mai zuwa shine bayanin yanayinsa, amfaninsa, shirye-shiryensa da bayanan aminci:

Hali:

N (alpha) -boc-N (gamma) - (9-xanthenyl) -L-asparagine shine m crystalline. Yana da launin fari ko rawaya kuma yana narkewa a cikin kaushi na halitta kamar dimethylformamide (DMF) da dichloromethane. Yana da ingantacciyar karko a yanayin zafin jiki, amma zai ruguje ƙarƙashin yanayin zafi mai ƙarfi ko yanayin alkali mai ƙarfi.

Amfani:

N (alpha) -boc-N (gamma) - (9-xanthenyl) -L-asparagine yana da mahimmancin ƙimar aikace-aikacen a cikin binciken miyagun ƙwayoyi. Ana iya amfani da shi a cikin haɗin magungunan peptide, irin su magungunan ƙwayoyin cuta da ƙwayoyin cuta na peptide precursor. Bugu da ƙari, ana iya amfani da shi azaman kayan aikin bincike a cikin ilmin halitta don bincika tsari da aikin takamaiman sunadaran ko peptides.

Hanyar Shiri:

Shirye-shiryen N (alpha) -boc-N (gamma) - (9-xanthenyl) -L-asparagine gabaɗaya ya ƙunshi amsawar matakai da yawa. Na farko, matsakaicin farko ya samo asali ne ta hanyar motsa jiki na aspartic acid-4, 4 '-diisopropylamino ester tare da p-aminobenzoic acid. Ana amfani da amsawar maye gurbin nucleophilic don gabatar da nailan oxyanthryl zuwa matsakaici don samar da samfurin ƙarshe.

Bayanin Tsaro:

N (alpha) -boc-N (gamma) - (9-xanthenyl) -L-asparagine shine reagent kirar kwayoyin halitta, kuma daidaitaccen aikin sa yana buƙatar bin ƙa'idodin aminci na dakin gwaje-gwaje. Saboda rashin cikakken bayanai daga binciken guba na wannan fili, sanin haɗarin haɗarinsa yana da iyaka. A lokacin sarrafa da amfani, ya kamata a kula don guje wa haɗuwa da fata da idanu kai tsaye, da kuma guje wa shakar foda ko iskar gas. Don tabbatar da aminci, ana ba da shawarar yin aiki a cikin dakin gwaje-gwaje da amfani da shi daidai da ƙa'idodin kayan kariya na sirri.