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Nicorandil (CAS# 65141-46-0) Featured Hoton
  • Nicorandil (CAS# 65141-46-0) 1

Nicorandil (CAS# 65141-46-0)

Abubuwan Sinadarai:

Tsarin kwayoyin halitta Saukewa: C8H9N3O4
Molar Mass 211.17
Yawan yawa 1.4271
Matsayin narkewa 92°C
Matsayin Boling 350.85°C
Wurin Flash 230°C
Solubility DMSO:> 10 mg/mL. Mai narkewa a cikin methanol, ethanol, acetone ko glacial acetic acid, dan kadan mai narkewa a cikin chloroform ko ruwa, kusan maras narkewa a cikin ether ko benzene.
Tashin Turi 1.58E-08mmHg a 25°C
Bayyanar Fari zuwa fari kamar crystalline foda
Launi fari zuwa farar fata
Merck 14,6521
Yanayin Ajiya 2-8 ° C
Fihirisar Refractive 1.7400 (kimanta)
MDL MFCD00186520
Abubuwan Jiki da Sinadarai Farar crystalline foda, mara wari ko ɗan wari, ɗaci. Mai narkewa a cikin methanol, ethanol, acetone ko acetic acid, mai narkewa a cikin chloroform ko ruwa, kaɗan ba sa narke cikin ether ko benzene. Matsayin narkewa 88.5-93.5 °c. Mugun guba LD50 berayen (mg/kg): 1200-1300 na baka, 800-1000 na jini.
Amfani Don rigakafin cututtukan zuciya, angina pectoris
Nazarin in vitro Nicorandil (100 mM) ya karu da iskar oxygen na flavoprotein, amma bai shafi membrane na yanzu ba, yana maido da tashoshin mitoK (ATP) da surfaceK (ATP) a mafi girma fiye da 10-ninka. Nicorandil yana rage mutuwar tantanin halitta a cikin samfurin ischemic granulation, wani sakamako na cardioprotective wanda aka toshe ta hanyar mitoK (ATP) mai hana tashar tashar 5-hydroxydecanoic acid amma ba ta surfaceK (ATP). Tasirin mai toshe tashar HMR1098. Nicorandil (100 mM) yana hana asarar TUNEL positivity, cytochrome C translocation, caspase-3 kunnawa, da mitochondrial membrane m (Delta (Psi) (m)). Binciken sel da aka yi da fluorescence Delta (Psi) (m) - mai nuna alama, tetramethylrhodamine ethyl ester (TMRE) ta hanyar walƙiya da aka kunna tantanin halitta ya nuna cewa, nicorandil yana hana Delta (Psi) (m) depolarization ta hanyar dogaro da hankali (EC (50) ) kusan 40 mM, jikewa 100 mM). A cikin duka ƙwayoyin da aka canza, Nicorandil ya kunna wani rauni mai rauni a ciki, tashar 80 pS K mai glibenclamide. A cikin sel HEK293T, Nicorandil ya fi son kunna tashar K(ATP) mai ɗauke da SUR2B. Nicorandil (100 mM) ya hana yawan adadin sel a cikin TUNEL-tabbatacce nuclei kuma ya karu 20 mM h2o2-induced caspase-3 aiki. Matsayin Nicorandil-dogara yana hana asarar DeltaPsim ta hanyar H2O2.
A cikin nazarin vivo Nicorandil (2.5 mg / kg kowace rana, po) a hade tare da Amlodipine (5.0 mg / kg kowace rana, po) kwanaki uku na aikin ya hana canje-canje da mayar da aikin enzyme zuwa matakan kusa da na berayen na al'ada.

Cikakken Bayani

Tags samfurin

Alamomin haɗari Xn - cutarwa
Lambobin haɗari R22 - Yana cutarwa idan an haɗiye shi
R41 - Hadarin mummunan lalacewa ga idanu
Bayanin Tsaro S26 - Idan ana hulɗa da idanu, kurkura nan da nan da ruwa mai yawa kuma ku nemi shawarar likita.
S39 – Sa ido/kariyar fuska.
WGK Jamus 3
RTECS US4667600
HS Code Farashin 2933990
Guba LD50 a cikin berayen (mg/kg): 1200-1300 baki; 800-1000 iv (Nagano)

 

Gabatarwa

Nicolandil, kuma aka sani da nicorandil amine, wani fili ne na kwayoyin halitta. Mai zuwa shine gabatarwa ga kaddarorin, amfani, shiri da bayanan aminci na nicorandil:

 

inganci:

- Nicorandil wani kauri ne mara launi mara launi wanda ke narkewa a cikin ruwa da abubuwan kaushi.

- Wani fili ne na alkaline wanda zai iya amsawa da acid don samar da mahadi na gishiri.

- Nicorandil yana da kwanciyar hankali a cikin iska, amma yana iya rubewa lokacin da aka fallasa shi zuwa yanayin zafi.

 

Amfani:

- Ana kuma iya amfani da Nicolandil a cikin haɓakar ƙwayoyin ƙwayoyin cuta, masu haɓaka hoto, da sauransu.

 

Hanya:

Nicolandil yawanci ana shirya shi ta hanyar amsawar dimethylamine da mahadi 2-carbonyl.

- Ana aiwatar da amsawa a ƙarƙashin yanayin alkaline kuma ana aiwatar da yanayin dumama a cikin wani ƙarfi mai dacewa.

 

Bayanin Tsaro:

- Nicorandil yana da ingantacciyar lafiya ga mutane a ƙarƙashin yanayi na gaba ɗaya.

- Duk da haka, ya kamata a kula don kauce wa haɗuwa da idanu, fata, da kuma numfashi.

- Sanya kayan kariya masu dacewa (PPE) kamar gilashin aminci, safar hannu da na'urorin numfashi.

- Lokacin amfani ko adana nicorandil, yakamata a kula don gujewa ƙonewa da yanayin zafi mai zafi.

 

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