tert-butyl 2 4-dioxopiperidine-1-carboxylate (CAS# 845267-78-9)

Tsarin kwayoyin halitta	Saukewa: C10H15NO4
Molar Mass	213.23
Yawan yawa	1.199
Matsayin Boling	373.8 ± 35.0 °C (An annabta)
Wurin Flash	179.9°C
Tashin Turi	8.72E-06mmHg a 25°C
pKa	10.67± 0.20 (An annabta)
Yanayin Ajiya	Ajiye a cikin duhu wuri, Rufe a bushe, Zazzabin ɗaki
Fihirisar Refractive	1.493
MDL	Saukewa: MFCD10566071

Cikakken Bayani

Lambobin haɗari	20/21/22 - Cutarwa ta hanyar shakarwa, a cikin hulɗa da fata kuma idan an haɗiye shi.
Bayanin Tsaro	S23 - Kar a shaka tururi. S24/25 - Guji hulɗa da fata da idanu.
WGK Jamus	3
HS Code	29337900

Amfani	2, 4-dipiperidon-1-formate tert-butyl formate shine haɗin abubuwan phenoxymethyl-dihydrothiazolopyridone Reactants a cikin samfurin, azaman zaɓin ingantaccen tsari mai daidaitawa (PAM) na mai karɓar glutamate 5 (mGlu5).
aikace-aikace	2, 4-dioperidone-1-tert-butyl formate an fi amfani dashi azaman tsaka-tsakin kwayoyin halitta da matsakaicin magunguna, kuma ana iya amfani dashi a cikin bincike na dakin gwaje-gwaje da tsarin ci gaba da tsarin hada magunguna.
shiri	mataki a: ƙara EDCI (191.7g) zuwa DMF (400mL) bayani na 3- (tert-butoxycarbonylamino) propionic acid (189.2g,1.0mol), meldamic acid (144.1g,1.0mol) da DMAP (135.0g,1.1mol) ) sanyaya da kankara wanka, 1.0mol). Sakamakon reactants an zuga su cikin dare a zafin jiki. An kashe maganin tare da 200 ml H2O. Sakamakon cakuda an ƙara dropwise zuwa H2O(2.0L) ƙarƙashin injin motsa jiki. An tace abin da aka samu mai ƙarfi kuma an wanke shi sosai da ruwa zuwa pH 7 don samun samfurin (283g, 90% yawan amfanin ƙasa). Mataki na B: Magani na 3- (2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl) -3-oxopropylcarbamate tert-butyl ester (100g,317.46mmol) a cikin toluene (1500mL) Ana yin zafi a 100 ° C na 4 hours. Ana sanyaya masu amsawa zuwa zafin daki kuma an tattara su a ƙarƙashin rage matsi don samun ɗanyen samfur. Samfurin (56g,83% yawan amfanin ƙasa) an tsarkake shi ta hanyar niƙa MTBE.